ABSTRACT
ABSTRACT Orofacial pain is related to tissues of the head, face, neck and all the intraoral structures; it is rather debilitating to the patient and also difficult to treat. There are relatively few studies dedicated to the use of natural products to alleviate orofacial pain in preclinical experiment models (performed in experimental animals which provide support for clinical trials). Main objectives of the present systematic review summarize the studies on natural products assessed in animal models for orofacial pain seeking to give evidence to future development of new pharmaceutical products to manage the orofacial pain. Our review includes a thorough search of literature using the terms of orofacial pain, facial pain, medicinal plants and natural products. This search was performed using to retrieve English language articles in Medline-PubMed, Scopus and Web of Science. A total of eighteen studies were included in our survey for the inclusion criteria. Firstly, this review identified 210 citations from electronic search, after removal of duplicates and screening for relevant titles and abstracts, a total of eighteen articles were selected to the inclusion criteria established. Our findings suggest that natural products can be a promising or a trump tool for the development of new drugs to treat orofacial pain conditions, but the researchers that deal with experimental preclinical trials of new drugs (including natural products or synthetic drugs) for orofacial pain conditions urgently need to show translational evidence (with clinical approach) of these compounds.
ABSTRACT
In the treatment of the mental disorders, the lack of adherenceto the pharmacotherapy is observed in about 50% of people and is responsible lot more morbidity, besides being the main cause of psychiatric morbidity and rehospitalization. This work sought to evaluate the adherenceto the medical treatment frompatients attended in a Primary Health Care Center in the municipal district of Aracaju – Sergipe. For that, an exploratory, descriptive and observational studywas accomplished, with transversal design, in the period from August 2011 to November 2011, carried outthrough interview applications. This research finds that more than 55% of the sample hadlow education; 41.4% were single and 42.8% presented other health problems, besides the mental disorder. Regarding to the knowledge level on the used medications, this variable presented good results, since 60% of the patients were classified in the category “know well”. Likewise, the results revealed that 49.3% of the investigated patients did not adhere to treatment, having as main causes of non-adherence the forgetfulness (53%), the lack of the medication in the health units (47%) or the lack of financial resources for the purchase of the medication (45%) – all these were considered as unintentional causes of non-adherence. Anyway it is an unpublished study in the outpatient attention context in Mental Health in the State, the results are expected to contribute for the evaluation and planning actions in the specialized component of the Pharmaceutical Assistance and in the precepts invigoration perspective of the psychiatric reform, focusing on the full approach of the attention towards the mental health and the rational use of psychotropic medicines.